abstract：:There is a growing awareness of the role that increased pulmonary vascular resistance (PVR) plays in many pathologies; therefore, assessment of pulmonary artery pressure (PAP) is an increasingly requested investigation in the critical care environment. This article will go through the basic concepts regarding PAP and ...

journal_title：Frontiers in pediatrics

authors： Skinner GJ

更新日期：2017-09-04 00:00:00

abstract：:The burden of asthma in childhood is considerable worldwide, although some populations are much more affected than others. Many attempts have been made by different investigators to identify the factors that could predict asthma development or persistence in childhood. In this review, the relation between atopic sensi...

journal_title：Frontiers in pediatrics

authors： Moustaki M,Loukou I,Tsabouri S,Douros K

更新日期：2017-07-31 00:00:00

abstract：:Bronchial asthma is one of the most common chronic inflammatory diseases of the airways. In the pathogenesis of this disease, the interplay among the genes, intrinsic, and extrinsic factors are crucial. Various combinations of the involved factors determine and modify the final clinical phenotype/endotype of asthma. O...

journal_title：Frontiers in pediatrics

authors： Jesenak M,Zelieskova M,Babusikova E

更新日期：2017-07-24 00:00:00

abstract：:We describe a giant gastric phytobezoar in a child with repaired congenital esophageal atresia. At age two, a gastric interposition (pull-up) procedure was performed for severe and recurrent esophageal strictures. For 12 months post-gastric interposition, he experienced frequent respiratory illnesses requiring hospita...

journal_title：Frontiers in pediatrics

authors： Chacko A,Masters BI,Isles A

更新日期：2017-06-19 00:00:00

abstract：:Bronchiectasis is a complex chronic respiratory condition traditionally characterized by chronic infection, airway inflammation, and progressive decline in lung function. Early diagnosis and intensive treatment protocols can stabilize or even improve the clinical prognosis of children with bronchiectasis. However, und...

journal_title：Frontiers in pediatrics

authors： Pizzutto SJ,Hare KM,Upham JW

更新日期：2017-05-29 00:00:00

abstract：:This mini review provides an overview of the issues and challenges inherent in autosomal recessive polycystic kidney disease (ARPKD), with a particular focus on the neurological factors and neurocognitive functioning of this population. ARPKD typically is discovered at the end of pregnancy or during the neonatal devel...

journal_title：Frontiers in pediatrics

authors： Hooper SR

更新日期：2017-05-15 00:00:00

abstract：:The association between atopic diseases is well known, and previous research has shown that having one atopic disease can predispose to having another. The link between asthma and food allergy has been well researched, but the exact relationship between the two atopic conditions is not fully understood. Food allergic ...

journal_title：Frontiers in pediatrics

authors： Foong RX,du Toit G,Fox AT

更新日期：2017-05-09 00:00:00

abstract：:Hypertension after kidney transplant is a frequent occurrence in pediatric patients. It is a risk factor for graft loss and contributes to the significant burden of cardiovascular disease (CVD) in this population. The etiology of posttransplant hypertension is multifactorial including donor factors, recipient factors,...

journal_title：Frontiers in pediatrics

authors： Charnaya O,Moudgil A

更新日期：2017-05-01 00:00:00

abstract：:Non-cystic fibrosis bronchiectasis (NCFB) has gained renewed interest, due to its increasing health-care burden. Annual mortality statistics in England and Wales showed that under 1,000 people die from bronchiectasis each year, and this number is increasing by 3% yearly. Unfortunately, there is a severe lack of well-p...

journal_title：Frontiers in pediatrics

authors： Nathan AM,de Bruyne JA,Eg KP,Thavagnanam S

更新日期：2017-04-24 00:00:00

abstract：:This review presents up-to-date understanding of immunotherapy in the treatment of children with allergic asthma. The principal types of allergen immunotherapy (AIT) are subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT). Both of them are indicated for patients with allergic rhinitis and/or asthma, ...

journal_title：Frontiers in pediatrics

authors： Tsabouri S,Mavroudi A,Feketea G,Guibas GV

更新日期：2017-04-21 00:00:00

abstract：:Cystic kidney diseases comprise a varied collection of hereditary disorders, where renal cysts comprise a major element of their pleiotropic phenotype. In pediatric patients, the term polycystic kidney disease (PKD) commonly refers to two specific hereditary diseases, autosomal recessive polycystic kidney disease (ARP...

journal_title：Frontiers in pediatrics

authors： Sweeney WE Jr,Avner ED

更新日期：2017-04-19 00:00:00

abstract：INTRODUCTION:The usefulness of qualitative or quantitative volumetric magnetic resonance imaging (MRI) in early detection of brain structural changes and prediction of adverse outcomes in neonatal illnesses warrants further investigation. Our aim was to correlate certain brain injuries and the brain volume of feeding-r...

journal_title：Frontiers in pediatrics

authors： Kashou NH,Dar IA,El-Mahdy MA,Pluto C,Smith M,Gulati IK,Lo W,Jadcherla SR

更新日期：2017-04-10 00:00:00

abstract：:Heart rate (HR) and blood pressure (BP) form the basis for monitoring the physiological state of patients. Although norms have been published for healthy and hospitalized children, little is known about their distributions in critically ill children. The objective of this study was to report the distributions of these...

journal_title：Frontiers in pediatrics

authors： Eytan D,Goodwin AJ,Greer R,Guerguerian AM,Laussen PC

更新日期：2017-03-17 00:00:00

abstract：:Dedicator of cytokinesis 8 (DOCK8) deficiency is an autosomal recessive, combined immunodeficiency within the spectrum of hyper-IgE syndromes. Epstein-Barr virus-positive lymphomatoid granulomatosis (LYG) (EBV + LYG) is a rare diagnosis and a previously unreported presentation of DOCK8 deficiency. A 10-year-old girl w...

journal_title：Frontiers in pediatrics

authors： Dimitriades VR,Devlin V,Pittaluga S,Su HC,Holland SM,Wilson W,Dunleavy K,Shah NN,Freeman AF

更新日期：2017-02-28 00:00:00

abstract：:Autosomal recessive polycystic kidney disease (ARPKD) is a rare monogenic disease with a severe phenotype often presenting prenatally or in early childhood. With its obligate renal and hepatic involvement, ARPKD is one of the most important indications for liver and/or kidney transplantation in childhood. Marked pheno...

journal_title：Frontiers in pediatrics

authors： Ebner K,Schaefer F,Liebau MC,ARegPKD Consortium.

更新日期：2017-02-16 00:00:00

abstract：OBJECTIVES:To determine the influence of family, peers, school, and physicians on exercise in pediatric oncology patients and evaluate the barriers to physical activity (PA) levels in this population. METHODS:A search of PubMed and Google Scholar resulted in 12 related articles. The articles were assessed for the infl...

journal_title：Frontiers in pediatrics

authors： Yelton L,Forbis S

更新日期：2016-12-19 00:00:00

abstract：OBJECTIVE:We investigated the relationship between influenza seasonality and outcome of very low birth weight infants (VLBWI) in a large observational cohort study of the German Neonatal Network. MATERIALS AND METHODS:Within the observational period (July 2009 until December 2014), five influenza seasons occurred (mea...

journal_title：Frontiers in pediatrics

authors： Härtel C,Humberg A,Viemann D,Stein A,Orlikowsky T,Rupp J,Kopp MV,Herting E,Göpel W

更新日期：2016-11-30 00:00:00

abstract：BACKGROUND:Studies suggest that children with congenital heart defects (CHD) are at risk for adverse intellectual functioning. However, factors related to lower intellectual functioning in this group are largely unknown. This study describes intellectual functioning in children with CHD in relation to severity of the h...

journal_title：Frontiers in pediatrics

authors： Ryberg C,Sunnegårdh J,Thorson M,Broberg M

更新日期：2016-11-17 00:00:00

abstract：INTRODUCTION:Adolescents and young adults with congenital heart disease (CHD) show a range of memory deficits, which can dramatically impact their clinical outcomes and quality of life. However, few studies have identified predictors of these memory changes. The purpose of this investigation was to identify predictors ...

journal_title：Frontiers in pediatrics

authors： Pike NA,Woo MA,Poulsen MK,Evangelista W,Faire D,Halnon NJ,Lewis AB,Kumar R

更新日期：2016-10-31 00:00:00

abstract：BACKGROUND:Impaired sleep is associated with negative effects on quality of life and daytime functioning. Higher rates of sleep disturbance are reported in children with various developmental disorders. However, little is known about sleep in children with developmental coordination disorder (DCD), a condition characte...

journal_title：Frontiers in pediatrics

authors： Wiggs L,Sparrowhawk M,Barnett AL

更新日期：2016-08-04 00:00:00

abstract：:Systemic inflammation and duration of immobilization are strong independent risk factors for the development of intensive care unit-acquired weakness (ICUAW). Activation of the pro-inflammatory transcription factor nuclear factor-κB (NF-κB) results in muscle wasting during disuse-induced skeletal muscle atrophy (ICU b...

journal_title：Frontiers in pediatrics

authors： Meduri GU,Schwingshackl A,Hermans G

更新日期：2016-08-02 00:00:00

abstract：:Anticoagulation is an imperfect science and is even more complicated in neonates and young children. The addition of the extracorporeal life support (ECLS) foreign circuit adds an additional layer of complexity. Anticoagulation goals during ECLS are to maintain a clot-free circuit and a hemostatically balanced patient...

journal_title：Frontiers in pediatrics

authors： Ryerson LM,Lequier LL

更新日期：2016-06-22 00:00:00

abstract：:Selective attention and efficacy are important components of scholastic performance in school children. While attempts are being made to introduce new methods to improve academic performance either as part of curricular or extracurricular activities in schools, the success rates are minimal. Hence, this study assessed...

journal_title：Frontiers in pediatrics

authors： Das M,Deepeshwar S,Subramanya P,Manjunath NK

更新日期：2016-06-15 00:00:00

abstract：:Pertussis, caused by Bordetella (B.) pertussis, a Gram-negative bacterium, is a highly contagious airway infection. Especially in infants, pertussis remains a major health concern. Acute infection with B. pertussis can cause severe illness characterized by severe respiratory failure, pulmonary hypertension, leucocytos...

journal_title：Frontiers in pediatrics

authors： Zlamy M

更新日期：2016-06-08 00:00:00

abstract：:Despite distinct epidemiology and outcomes, pediatric acute respiratory distress syndrome (PARDS) is often managed based on evidence extrapolated from treatment of adults. The impact of non-pulmonary processes on mortality as well as the lower mortality rate compared to adults with acute respiratory distress syndrome ...

journal_title：Frontiers in pediatrics

authors： Yehya N,Thomas NJ

更新日期：2016-05-13 00:00:00

abstract：INTRODUCTION:Hypospadias is a male congenital condition where the opening of the urethral meatus is not located in the typical anatomical position. It has been a challenge for empirical studies to ascertain the level of concordance of opinion among parents and urologists with regard to surgical outcomes according to hy...

journal_title：Frontiers in pediatrics

authors： Pérez-Brayfield MR,Jorge JC,Avilés LA,Díaz J,Ortiz V,Morales-Cosme W

更新日期：2016-01-25 00:00:00

abstract：BACKGROUND:Pulmonary hypertension (PH) is frequently associated with an increase in sympathetic tone. This may adversely affect cardiac autonomic control. Knowledge about the clinical impact of autonomic dysfunction in patients with PH is limited. We aimed to assess whether parameters of heart rate variability (HRV) ar...

journal_title：Frontiers in pediatrics

authors： Latus H,Bandorski D,Rink F,Tiede H,Siaplaouras J,Ghofrani A,Seeger W,Schranz D,Apitz C

更新日期：2015-07-07 00:00:00

abstract：:Thrombocytopenia and pancytopenia, occurring in patients with Fanconi anemia (FA), are interpreted either as progression to bone marrow failure or as developing myelodysplasia. On the other hand, immune thrombocytopenia (ITP) represents an acquired and often self-limiting benign hematologic disorder, associated with p...

journal_title：Frontiers in pediatrics

authors： Karastaneva A,Lanz S,Wawer A,Behrends U,Schindler D,Dietrich R,Burdach S,Urban C,Benesch M,Seidel MG

更新日期：2015-06-08 00:00:00

abstract：UNLABELLED:Pediatric acute encephalopathy (AE) was sometimes attributed to virus infection. However, viral infection does not always result in AE. The risk factors for developing infantile AE upon virus infection remain to be determined. Here, we report an infant with AE co-infected with human herpesvirus-6 (HHV-6) and...

journal_title：Frontiers in pediatrics

authors： Nakata K,Kashiwagi M,Masuda M,Shigehara S,Oba C,Murata S,Kase T,Komano JA

更新日期：2015-04-02 00:00:00

abstract：BACKGROUND:Bloodstream infection (BSI) is one of the significant causes of morbidity and mortality encountered in a neonatal intensive care unit, especially in developing countries. Despite the implementation of infection control practices, such as strict hand hygiene, the BSI rate in our hospital is still high. The us...

journal_title：Frontiers in pediatrics

authors： Rundjan L,Rohsiswatmo R,Paramita TN,Oeswadi CA

更新日期：2015-03-16 00:00:00

abstract：:The current study investigated the differences between intact and non-intact families in family processes, including systematic family functioning, parental behavioral control, parental psychological control, and parent-child relational qualities. The participants were 3,328 Secondary One students, with a mean age of ...

journal_title：Frontiers in pediatrics

authors： Shek DT,Xie Q,Lin L

更新日期：2015-01-29 00:00:00

abstract：OBJECTIVES:Nationally accredited simulation courses such as advance pediatric life support and pediatric advance life support are recommended for health care professionals (HCPs) at two yearly intervals as a minimum requirement, despite literature evidence suggesting rapid decline in knowledge shortly after course comp...

journal_title：Frontiers in pediatrics

authors： Ojha R,Liu A,Champion BL,Hibbert E,Nanan RK

更新日期：2014-11-24 00:00:00

abstract：UNLABELLED:Even though in the corporate world psychological science has been widely used, the formal use of evidence-based psychology in important areas of clinical medicine has been scanty at best. It was the aim of this study to determine the efficacy of a psychologist-led 2-week nurse educator training on the infect...

journal_title：Frontiers in pediatrics

authors： Van Rostenberghe H,Short J,Ramli N,Geok TB,Subramaniam S,Che Yaakob CA,Othman A,Ibrahim NR,Ho J,Mohamed Z,Hasan H

更新日期：2014-11-19 00:00:00

abstract：:Excessive oxygen (O2) can cause tissue injury, scarring, aging, and even death. Our laboratory is studying O2-sensing pulmonary neuroendocrine cells (PNECs) and the PNEC-derived product gastrin-releasing peptide (GRP). Reactive oxygen species (ROS) generated from exposure to hyperoxia, ozone, or ionizing radiation (RT...

journal_title：Frontiers in pediatrics

authors： Sunday ME

更新日期：2014-07-18 00:00:00

abstract：:Animal models provide convenient and clinically relevant tools in the research on neurodegenerative diseases. Studies on developmental disorders extensively rely on the use of laboratory rodents. The present mini-review proposes an alternative translational model based on the use of fetal bovine brain tissue. The bovi...

journal_title：Frontiers in pediatrics

authors： Peruffo A,Cozzi B

更新日期：2014-07-10 00:00:00

abstract：:The evaluation and treatment of the heterogeneous group of kidney diseases poses a challenging field in pediatrics. Many of the pediatric disorders resulting in severe renal affection are exceedingly rare and therapeutic approaches have remained symptomatic for most of these disease entities. The insights obtained fro...

journal_title：Frontiers in pediatrics

authors： Liebau MC

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Phenylketonuria (PKU) is caused by the inherited defect of the phenylalanine hydroxylase enzyme, which converts phenylalanine (Phe) into tyrosine (Tyr). Neonatal screening programs and early treatment have radically changed the natural history of PKU. Nevertheless, an increased risk of neurocognitive and psy...

journal_title：Frontiers in pediatrics

authors： Leuzzi V,Mannarelli D,Manti F,Pauletti C,Locuratolo N,Carducci C,Carducci C,Vanacore N,Fattapposta F

更新日期：2014-06-23 00:00:00

abstract：:Response to early intervention programs in autism is variable. However, the factors associated with positive versus poor treatment outcomes remain unknown. Hence the issue of which intervention/s should be chosen for an individual child remains a common dilemma. We argue that lack of knowledge on "what works for whom ...

journal_title：Frontiers in pediatrics

authors： Vivanti G,Prior M,Williams K,Dissanayake C

更新日期：2014-06-20 00:00:00

abstract：:In recent decades, new research into the developmental defects and pathophysiological basis of congenital diaphragmatic hernia (CDH) has revealed opportunities for the development of innovative therapies. Importantly, the use of animal models to represent this anomaly in the laboratory has resulted in the discovery of...

journal_title：Frontiers in pediatrics

authors： Chiu PP

更新日期：2014-04-29 00:00:00

abstract：BACKGROUND:Although histologic chorioamnionitis (HCA) is known to be associated with poor outcomes in preterm infants, its clinical significance among term infants is not clearly known. OBJECTIVES:To investigate the utility of HCA in determining early onset clinical sepsis (EOCS) among term newborns. METHODS:The inci...

journal_title：Frontiers in pediatrics

authors： Cuna A,Hakima L,Tseng YA,Fornier B,Islam S,Quintos-Alagheband ML,Khullar P,Weinberger B,Hanna N

更新日期：2014-04-04 00:00:00